info@sprs-therapy.ru


Human Stem Cells Institute OJSC (HSCI) is a Russian public biotech company founded in 2003.


HSCI is engaged in drug discovery, R&D and marketing of innovative proprietary products and services in the field of regenerative medicine, bio-insurance, medical genetics, including reproductive genetics, gene therapy and biopharmaceutics.


The Company aims to foster a new culture of medical care – developing new health care opportunities in such areas as personalized and preventive medicine.


HSCI owns the largest family cord blood stem cell bank in Russia – Gemabank, as well as the reproductive cell and tissue bank Reprobank (personal storage and donation).


The Company launched Neovasculgen®, the first-in-class gene-therapy drug for treating Peripheral Arterial Disease, including Critical Limb Ischemia, and also introduced the innovative cell technology SPRS-therapy, which entails the use of autologous dermal fibroblasts to repair skin damage due to aging and other structural changes.


HSCI is implementing a socially significant project to create its own Russia-wide network of Genetico medical centers & testing lab to provide a range of genetic diagnostic and consulting services with the aim of early identification, prediction and prophylactic treatment of genetic disorders (incl. PGD and NIPT among others).


The Company actively promotes its products on the Russian market and intends to open new markets throughout the world.


HSCI is listed on the Innovation & Investment Market (iIM) of the Moscow Exchange (ticker ISKJ). The Company conducted its IPO in December 2009, becoming the first Russian biotech company to go public.

www.eng.hsci.ru

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Do you know how to increase the collagen level in your skin?

Collagen-containing creams

During many years, there were attempts of using collagen to remove wrinkles. Nevertheless, one should remember that in order to achieve a good clinical effect, collagen should enter the derma, i.e., the middle layer of the skin. However, the collagen molecule is too big to penetrate the derma as a cream component after its application on the skin. Nevertheless, even such a mode of the use of collagen facilitates skin moisturizing and temporary concealing of small shallow wrinkles.

Introduction of collagen by injections

Another approach to wrinkle correction is intracutaneous collagen injections. Collagen is injected under the wrinkle elevating it and, thus, the wrinkle becomes practically invisible. This procedure has apparent esthetic effect and, unfortunately, a number of disadvantages, in particular, an allergic reaction to allogenic protein. 

The use of patient's own skin fibroblasts 

An efficient procedure lacking adverse side effects and used for correction of wrinkles and the other age-related skin changes is intracutaneous injections of autologous (i.e., patient's own) skin cells, fibroblasts, which are obtained from patient's small skin sample. These cells are very interesting since they intensively produce collagen, elastin, hyaluronic acid, and the other important skin components and are capable of maintaining this production activity being injected into the skin. This, in turn, leads to efficient correction of wrinkles and the other age-related skin defects. At present, this cell technology received international acknowledgement, in particular, it is intensively used in Russia (the SPRS therapy) and in the USA (the LAVIV therapy). 

The use of "key" amino acids 

As the other proteins, collagen consists of amino acids, the main of which are glycine, proline, and lysine. By increasing the content of these amino acids in the skin, we promote collagen production in the skin.

Copper-containing proteins 

Microelements are essential components for collagen production in the skin. One of such microelements is copper. The increase of the copper level in the skin promotes collagen synthesis. However, one should remember that this microelement should be used only in the protein-bound form (since copper in the unbound form participates in formation of free radicals damaging the skin). Such copper-containing proteins stimulate hair growth and are capable of efficient correction of wrinkles.

17.04.2013