Human Stem Cells Institute OJSC (HSCI) is a Russian public biotech company founded in 2003.

HSCI is engaged in drug discovery, R&D and marketing of innovative proprietary products and services in the field of regenerative medicine, bio-insurance, medical genetics, including reproductive genetics, gene therapy and biopharmaceutics.

The Company aims to foster a new culture of medical care – developing new health care opportunities in such areas as personalized and preventive medicine.

HSCI owns the largest family cord blood stem cell bank in Russia – Gemabank, as well as the reproductive cell and tissue bank Reprobank (personal storage and donation).

The Company launched Neovasculgen®, the first-in-class gene-therapy drug for treating Peripheral Arterial Disease, including Critical Limb Ischemia, and also introduced the innovative cell technology SPRS-therapy, which entails the use of autologous dermal fibroblasts to repair skin damage due to aging and other structural changes.

HSCI is implementing a socially significant project to create its own Russia-wide network of Genetico medical centers & testing lab to provide a range of genetic diagnostic and consulting services with the aim of early identification, prediction and prophylactic treatment of genetic disorders (incl. PGD and NIPT among others).

The Company actively promotes its products on the Russian market and intends to open new markets throughout the world.

HSCI is listed on the Innovation & Investment Market (iIM) of the Moscow Exchange (ticker ISKJ). The Company conducted its IPO in December 2009, becoming the first Russian biotech company to go public.

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Darsonvalization: weak currant and weak effect

Another method which is widely and gladly applied in cosmetology is termed darsonvalization on the name of Arsene d'Arsonval, a French physiologist and physicist, who at the end of 19 century revealed the influence of alternating current of high frequency on living things. The inventor developed a specific device that allowed one to use such current for therapeutic purposes. The device operation is based on the alternating pulse current of high frequency (up to 500 kHz), high voltage (up to 25 kV), and low intensity (0.02 mA) which supplied by short impulses (50–100 µsec) with frequency modulation of 50 Hz.

 In fact, this therapeutic procedure is familiar to many people who ever visited physiotherapy rooms in clinics. The procedure is based on the fact that under the influence of alternating current of high frequency, small blood vessels are widened, blood microcirculation is intensified, vessel tonus is increased, and muscle spasms are vanished. All these effects together with the influence on peripheral nerves lead to the decrease of pain in muscles and joints. In addition, the blood pressure is decreased, the blood circulation in the brain is improved, and the tissue regeneration is accelerated. When used in cosmetology, darsonvalization has all the above-listed effects on skin blood vessels, thus, improving blood microcirculation and cell nutrition in the skin, which leads to the increase of skin elasticity and prevents wrinkle formation.

Disadvantages and contraindications for darsonvalization

Darsonvalization can not remove already formed wrinkles. Besides, darsonvalization decreases the activity of sweat and sebaceous glands making the skin drier. This is important to cure the oily and porous skin. Another crucial effect of darsonvalization is its antibacterial action: electrical charge destroys bacteria and facilitates acne healing, which is important for treatment of acne and problem skin.

Thus, darsonvalization is indicated in cosmetology to treat mature skin having low turgor as well as to treat acne, oily, and porous skin.

This procedure also has contraindications including cuperosis (the broadened capillary network on the face), abnormal blood coagulation, thrombophlebitis, and heart arrhythmia. In addition, to achieve a desirable effect, one needs to spend a considerable amount of time: dozens of sessions, each session lasts for about 10 minutes.

The other methods of skin rejuvenation: an alternative to darsonvalization

In this respect, a perfect alternative to darsonvalization is the SPRS therapy, an efficient and safe technology based on the use of autologous (i.e., patient's own) skin cells (fibroblasts). Fibroblasts are the main skin cells which are responsible for production of skin "youth" components: collagen, elastin, and hyaluronic acid; as well as for production of growth factors and cytokines improving, in particular, the state of blood vessels and skin microcirculation.

Briefly, the SPRS therapy can be described as follows: patient's skin sample of4 mmin size is used to obtain a cell suspension containing cultivated autologous fibroblasts at the specialized laboratory of the Human Stem Cells Institute. The course of the skin therapy consists of 2 procedures separated with a one-month interval. The obtained cell suspension (the SPRS preparation) is delivered to the cosmetological clinic immediately before each procedure. The cells are injected according to the special procedure intracutaneously (into the papillary layer of the derma) by tunnel mode using special mesotherapeutic needles which allows one to evenly distribute (with the adequate cell density) new functionally active fibroblasts throughout the skin region that requires correction. This completely excludes patient's body immune response since only patient's own cells are used for the procedure.

The autologous fibroblasts injected into the skin efficiently correct the age-related skin changes since, being transplanted into the skin, they intensively produce collagen, elastin, and the other important skin "youth" components. As a result, the skin microstructure is restored and the skin density and elasticity is increased whereas the amount and depth of wrinkles is decreased. Owing to production of proangiogenic growth factors by injected fibroblasts, the state of blood vessels is also improved that is why this technology is not contraindicated for patients with cuperosis but, in contrast to darsonvalization, is quite efficient. 

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