Human Stem Cells Institute OJSC (HSCI) is a Russian public biotech company founded in 2003.

HSCI is engaged in drug discovery, R&D and marketing of innovative proprietary products and services in the field of regenerative medicine, bio-insurance, medical genetics, including reproductive genetics, gene therapy and biopharmaceutics.

The Company aims to foster a new culture of medical care – developing new health care opportunities in such areas as personalized and preventive medicine.

HSCI owns the largest family cord blood stem cell bank in Russia – Gemabank, as well as the reproductive cell and tissue bank Reprobank (personal storage and donation).

The Company launched Neovasculgen®, the first-in-class gene-therapy drug for treating Peripheral Arterial Disease, including Critical Limb Ischemia, and also introduced the innovative cell technology SPRS-therapy, which entails the use of autologous dermal fibroblasts to repair skin damage due to aging and other structural changes.

HSCI is implementing a socially significant project to create its own Russia-wide network of Genetico medical centers & testing lab to provide a range of genetic diagnostic and consulting services with the aim of early identification, prediction and prophylactic treatment of genetic disorders (incl. PGD and NIPT among others).

The Company actively promotes its products on the Russian market and intends to open new markets throughout the world.

HSCI is listed on the Innovation & Investment Market (iIM) of the Moscow Exchange (ticker ISKJ). The Company conducted its IPO in December 2009, becoming the first Russian biotech company to go public.

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Hand skin correction

Our hands, as Dr. V. Mitz said, are precious gift but they also age with time. The first signs of hand skin aging appear quite early since, in addition to the natural processes of biological aging, the hand skin is subjected to constant influence of environment including UV-light irradiation. 

During aging, the skin on the back of hands becomes thin; the natural fat layer is destroyed and subcutaneous veins are protruded. As a result of chronic damage by the UV light, the signs of hyperpigmentation and solar lentigo appear on the hand skin, the skin turgor and elasticity is decreased, and wrinkles are formed on the hand skin.

Modern methods of correction of the age-related hand skin changes

The modern arsenal of methods to correct the age-related hand skin changes is sufficiently broad. These methods can be conditionally divided onto 3 groups. The first group includes surgical methods, out of which the most popular method is lipofilling, i.e., the subcutaneous transplantation of autologous fat in order to compensate the loss of soft tissues volumes during aging. The second group of methods includes the standard cosmetological methods, such as biorevitalizing (injections of hyaluronic acid preparations into the hand skin), plasma therapy, device methods (radio waves and laser technologies), microdermabrasion, and chemical peelings. 

The aim of these methods is to stimulate the main skin components, fibroblasts, to work intensively (to produce collagen, elastin, and the other components of dermal extracellular matrix) and to compensate the lost volume of the derma. However, since with age the amount and activity of fibroblasts in the skin are decreased (according to the data of American scientists, collagen production in old people is decreased by approximately 75% as compared with the young people skin, whereas the total amount of fibroblasts is decreased by approximately 40% in average) the final result not always corresponds patients' expectations.

The efficient method of rejuvenation of the hand skin

The fundamentally different approach is used in the third group of methods belonging to the field of regenerative medicine. This group of methods includes the SPRS therapy. This method is based on injections into patient's skin his (or her) own fibroblasts which, being injected into the skin, regenerate the skin by triggering natural physiological mechanisms of skin regeneration. According to the morphological data, after transplantation, the cultivated autologous fibroblasts are entirely integrated into the derma; their biosynthetic activity is maintained at least for 12 months. As a result, the content of collagen fibers is increased in the skin, the skin thickness is increased, and the amount and depth of wrinkles are decreased, which promotes the restoration of hands beauty.

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