Vitamin A: a simple way to increase the collagen level in the skin
Local application of products on the basis of retinoic acid (in the form of creams containing vitamin A in the concentration of 0.025–1% for 1 to 12 months) results in a visible improvement of skin condition.
The matter is that vitamin A promotes the increase of collagen level in the derma owing to its interaction with receptors on the surface of skin fibroblasts. Moreover, the use of products on the basis of retinoic acid leads to the decrease of metalloproteinase activity and, therefore, to the decrease of skin collagen destruction. At the same time, genes encoding procollagen types I and III are activated, which leads to the increase of the amount of newly formed collagen fibers.
As a result, after a long-term application of vitamin A-containing products, the increase of newly formed collagen level is observed in the skin as well as the destruction of "old" collaged fibers is diminished, which leads to the increase of skin density and to the correction of wrinkles. That is why creams containing vitamin A can be efficiently used to correct both chronological age-related skin changes and UV light-related skin changes.
Nevertheless, one should keep in mind that vitamin A is an active substance possessing photo-sensibilizing effect which must be applied overnight (possibly during cold seasons) and is not applicable for persons under age of 35–40 years.
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